Wellbutrin and jaw clenching

We are incredibly fortunate to live in a time when some of our most painful and debilitating medical conditions can be well-controlled with prescription medications, allowing us to enjoy a more pleasurable quality of life.

Federal government websites often end in. The site is secure. Antidepressant-associated movement disorders are a well-described phenomenon. However, antidepressant-associated bruxism, jaw pain, or jaw spasm, while reported in dental literature, is less commonly recognized among neurologists. We summarize the clinical features and treatment of antidepressant-associated bruxism and associated jaw pain through a systematic review of case reports. Antidepressant-associated bruxism may occur in pediatric and adult patients, most commonly among female patients.

Wellbutrin and jaw clenching

Why do SSRIs cause jaw clenching? While the exact mechanism is unknown, it appears that SSRIs trigger jaw clenching because of their effect on the level of neurotransmitters like serotonin in the brain. These neurotransmitters control mood, but they also contribute to movement regulation. Recent clinical evidence points to a significant association between selective serotonin reuptake inhibitor SSRI antidepressant drugs and jaw clenching. The effect is not permanent, as SSRI jaw clenching starts around 3 weeks after starting the medication and resolves 3 weeks after stopping. In a article in the journal BMC Psychiatry, researchers found that compared to all other medications, your chances of reporting bruxism when taking antidepressants are 10 times higher than they are with any other type of medication. The same researchers compared the classes of antidepressant drugs to see which were more closely associated with bruxism. The two related classes of antidepressants with the strongest association with clenching were the SSRIs and the serotonin-norepinephrine reuptake inhibitors SNRIs. Out of these, Zoloft, Celexa, and Trintellix had a statistically significant association with bruxism, according to the study parameters. In the same article, researchers compared three different classes of antidepressants to see their relationship with jaw clenching. Please note that any medication changes should be directed by a healthcare professional. The mechanisms between SSRIs and jaw clenching are poorly understood. Serotonin, norepinephrine, and dopamine are all neurotransmitters that determine your mood. Antidepressant drugs like SSRIs and SNRIs try to improve depression or anxiety disorders by altering the levels of these neurotransmitters in your brain.

First, buspirone is a serotonin 1A 5HT 1A partial agonist at both presynaptic and postsynaptic receptors at various sites, including the amygdala, prefrontal cortex, thalamus, and striatum.

Certain medications and drugs act on the brain by stimulating it. The results suggest brain stimulation is believed to contribute to grinding. Scientific data shows several neurotransmitters are involved in the effect of various drugs on bruxism. The dopaminergic systems in the striated body and the frontal lobe of the brain are of special importance, since hyperactivity generates bruxism, particularly the mandibular movement with tooth grinding. Selective Serotonin Reuptake Inhibitors SSRIs — Prescribed for depression, obsessive-compulsive disorder, anxiety, panic disorder, post-traumatic stress disorder, seasonal affective disorder, and depressive episodes of bipolar disorder, social phobia, premenstrual dysphoric disorder and menopause. In some reported cases where bruxism is thought to be initiated by SSRIs, decreasing the dosage may resolve the issue. Other sources state reports of SSRIs causing bruxism are rare and it only happens with long-term use.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. Other side effects not listed may also occur in some patients.

Wellbutrin and jaw clenching

Objective: To report a case of acute dystonia consisting of neck stiffness, trismus, and unilateral temporomandibular joint TMJ pain and subluxation secondary to an increase in sustained-release SR bupropion. Case summary: A year-old white man with a history of chronic low-back pain and tension headaches, taking no other medications, was started on bupropion SR mg once a day for depression. The dosage was increased to mg SR twice a day and eventually augmented with buspirone 15 mg 3 times a day. He developed bilateral trismus, inability to rotate his head laterally, and spontaneous left TMJ subluxation. Symptoms recessed with discontinuation of both medications and failed to reappear with a trial of buspirone 15 mg 3 times a day alone. A retrial of bupropion alone evidenced no adverse effects at a dosage of mg SR once a day. However, when the dosage was increased to mg SR twice a day, the patient reexperienced initial signs of neck stiffness, jaw muscle tightness, and left TMJ subluxation within hours. Discussion: Medication-induced focal dystonias usually present with dramatic head most frequently oral-buccal and neck muscle spasm with occasional jaw clenching, bruxism, and TMJ syndrome. In this case, the rapid onset of neck and jaw symptoms within hours of an increase of bupropion SR from mg once a day to mg twice a day suggest that the patient may have been sensitized by an initial trial of bupropion and buspirone, or by the increased dose of bupropion alone. Both agents are reported to interact with both the dopaminergic and serotonergic systems.

Dymo d1 tape

Time to onset of symptoms, in most cases, was between 3 and 4 weeks. Abstract Purpose of review Antidepressant-associated movement disorders are a well-described phenomenon. The average age was Recent findings Antidepressant-associated bruxism may occur in pediatric and adult patients, most commonly among female patients. Children and Bruxism. Next, talk to the dentist to find out if a night guard or occlusal guard can provide the necessary protection as long as you are taking the medication. Bruxism associated with serotonin reuptake inhibitors: two cases. This may also explain why buspirone is ineffective in treating idiopathic bruxism. Psychosomatics ; 41 — J Orofac Pain ; 15 — Finally, further prospective study would be helpful to elucidate the true underlying effect of the interventions described above compared to watchful waiting for symptom resolution. J Clin Psychopharmacol ; 34 Mental health medications [online]. Finally, in patients who are not experiencing severe symptoms and who are satisfied with antidepressant effects otherwise, simple monitoring for spontaneous resolution of symptoms may be considered.

Our pharmacist answers the latest question regarding what to do if your SSRI causes jaw clenching. I'm on citalopram 40mgs daily, bupropion sr mgs daily, hydroxyzine 25mgs 3x daily, trazodone mgs nightly.

Study funding No targeted funding reported. The patient's symptoms were initially thought to be due to idiopathic refractory temporomandibular joint disorder with a possible oromandibular dystonia given her jaw opening limitations on the right side. Stahl SM. J Clin Psychiatry ; 73 Table 2 Patient data. About Contact My Account. J Clin Psychiatry ; 60 — If the patient can tolerate dose reduction or drug discontinuation, this may likewise be a reasonable course of action. Principally, the analysis above is based on a collection of case reports, and does not represent randomized or placebo-controlled study data. Indian J Psychol Med ; 37 — The case of spontaneous symptom resolution without intervention, as mentioned, reported resolution after 4 weeks. Symptoms may also resolve over time without pharmacologic intervention. Data from the pooled case reports above suggest that antidepressant-associated bruxism may occur in patients of any age, including children.