Pharmgkb

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, pharmgkb, pharmgkb, we recommend you use a more up to date browser or turn pharmgkb compatibility mode in Internet Explorer.

The Pharmacogenomics Knowledgebase PharmGKB is a publicly available, online knowledge base responsible for the aggregation, curation, integration and dissemination of knowledge regarding the impact of human genetic variation on drug response. It has been managed at Stanford University since its inception in In order to achieve this goal, PharmGKB manually curates PGx information from the primary literature, and then stores it in the knowledge base. This information can be aggregated, allowing PharmGKB to identify consistent genetic variant -drug response interactions. Variant-drug interactions with a large amount of supporting evidence may then be considered for potential clinical implementation. PharmGKB has many different types of PGx-related information available through the website, discussed in the sections below.

Pharmgkb

PharmGKB website. The PharmGKB is a pharmacogenomics knowledge resource that encompasses clinical information including dosing guidelines and drug labels, potentially clinically actionable gene-drug associations and genotype-phenotype relationships. PharmGKB collects, curates and disseminates knowledge about the impact of human genetic variation on drug responses through the following activities:. All Rights Reserved. Remember me. Forgot password. PGRN Leadership. PGRN Bylaws. Committees Psychiatry Interest Group. Oncology Interest Group. Join Membership Application. Member Login. Travel Awards. Job Board Job Board Payment.

In response to assessment of the field and feedback from users, pharmgkb, the priorities for pharmgkb next 5 years include:.

Federal government websites often end in. The site is secure. The Pharmacogenomics Knowledge Base, PharmGKB, is an interactive tool for researchers investigating how genetic variation affects drug response. Users can search and browse the knowledgebase by genes, variants, drugs, diseases, and pathways. Registration is free to the entire research community, but subject to agreement to use for research purposes only and not to redistribute.

Federal government websites often end in. The site is secure. The Pharmacogenomics Knowledge Base, PharmGKB, is an interactive tool for researchers investigating how genetic variation affects drug response. Users can search and browse the knowledgebase by genes, variants, drugs, diseases, and pathways. Registration is free to the entire research community, but subject to agreement to use for research purposes only and not to redistribute. Registered users can access and download data to aid in the design of future pharmacogenetics and pharmacogenomics studies. In the National Institutes of Health recognized the need for a freely available collection of high quality genotypic and phenotypic data from pharmacogenetics and pharmacogenomics studies, and announced the funding of the Pharmacogenetics Research Network PGRN. These groups are united by the purpose of developing and populating a public database, which was envisioned as a tool for all researchers in the field. PharmGKB captures pharmacogenomic relationships in a structured format so that it can be searched, interrelated, and displayed according to the researchers interests, either for manual inspection or to download for further analyses. The knowledge base is valuable both to the researcher who is interested in a specific single nucleotide polymorphism and its influence on a particular drug treatment and to the researcher interested in a disease or drug and looking for candidate genes which may affect disease progression or drug response.

Pharmgkb

The Pharmacogenomics Knowledge Base, PharmGKB, is an interactive tool for researchers investigating how genetic variation affects drug response. Users can search and browse the knowledgebase by genes, variants, drugs, diseases, and pathways. Registration is free to the entire research community, but subject to agreement to use for research purposes only and not to redistribute. Registered users can access and download data to aid in the design of future pharmacogenetics and pharmacogenomics studies.

Adventure time the red splinter

Pharmspresso: a text mining tool for extraction of pharmacogenomic concepts and relationships from full text. Caroline F. Pharmacogenomics J ; 2 : 48— It is freely available and accessible to everyone from researchers to clinicians to everyday citizens. Sorry, a shareable link is not currently available for this article. TPMT alleles. Email: ude. The enormous number of publications annotated on PharmGKB, combined with the varied number of variant annotations on each publication, leads to a large amount of data. All variant annotations contain a standardized sentence, which allows results to be easily compared and contrasted between studies throughout the knowledge base. The PharmGKB organizes its data into five high-level categories: data pertinent to 1 variation in clinical outcome, 2 variation in pharmacodynamics and drug responses, 3 variation in pharmacokinetics, 4 variation in molecular and cellular functional assays, and 5 variation in genetic sequence.

Federal government websites often end in. The site is secure.

Our current process for literature annotation uses NLP to suggest possible genes, drugs, and diseases to the curator [ 14 , 15 ] but after reading the article the curator decides which are appropriate. VIPs are overviews of important genes involved in drug response. Platelet aggregation pathway. PMC Copyright notice. Thomae BA et al. Preemptive clinical pharmacogenetics implementation: Current programs in five US medical centers. Drug Metab Rev. If the label states a test "should be" performed, this is also interpreted as a requirement. Klein, T. While the mission of PharmGKB has evolved and expanded over time, and the general public and clinicians are now more frequent users, the knowledgebase continues to maintain its collection of annotated literature. Desta Z, et al. Download citation. Content regarding anticancer drug treatment affected by germline and somatic genetic variation is compiled on a single page for easy browsing.