Dppc full form

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Dipalmitoylphosphatidylcholine DPPC is a phospholipid and a lecithin consisting of two C 16 palmitic acid groups attached to a phosphatidylcholine head-group. It is the main constituent of pulmonary surfactants, which reduces the work of breathing and prevents alveolar collapse during breathing. It also plays an important role in the study of liposomes and human bilayers. Lung surfactant LS is a surface-active material produced by most air-breathing animals for the purpose of reducing the surface tension of the water layer where gas exchange occurs in the lungs, given that the movements due to inhalation and exhalation may cause damage if there is not enough energy to sustain alveolar structural integrity. While DPPC itself already has the ability to reduce the surface tension of the alveolar liquid, the proteins and other lipids in the surfactant further facilitate the adsorption of oxygen into the air-liquid interface. DPPC is a variant of phosphatidylcholine. Its structure includes both a hydrophilic "head" and hydrophobic "tails", and it is this arrangement that makes it able to reduce the surface tension of the water layer.

Dppc full form

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Federal government websites often end in. The site is secure. Phosphatidylcholine PC is the major phospholipid of pulmonary surfactant and it is hypothesized that PC and its subspecies modulate the functions of alveolar macrophages. The most abundant of these subspecies is dipalmitoylphosphatidylcholine DPPC. This study was undertaken to determine the effect of PC on monocyte function using a human monocytic cell line, MonoMac-6 MM6. When DPPC was replaced with 1-palmitoylarachidonoyl phosphatidylcholine PAPC there was no inhibition and in contrast a significant increase in oxidant production was observed. These results suggest that DPPC, the major component of pulmonary surfactant, may play a role in modulating leucocyte inflammatory responses in the lung.

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Dppc full form

Federal government websites often end in. The site is secure. Phosphatidylcholine PC is the major phospholipid of pulmonary surfactant and it is hypothesized that PC and its subspecies modulate the functions of alveolar macrophages. The most abundant of these subspecies is dipalmitoylphosphatidylcholine DPPC. This study was undertaken to determine the effect of PC on monocyte function using a human monocytic cell line, MonoMac-6 MM6. When DPPC was replaced with 1-palmitoylarachidonoyl phosphatidylcholine PAPC there was no inhibition and in contrast a significant increase in oxidant production was observed. These results suggest that DPPC, the major component of pulmonary surfactant, may play a role in modulating leucocyte inflammatory responses in the lung. The thin epithelial barrier, which comprises the alveolar surface for gaseous exchange, is uniquely vulnerable to damage related to inflammatory changes. These may result from particulate insults, oxidant gases or damage secondary to infection.

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The choline radical constitutes the polar hydrophilic head; it is oriented towards and extends into the alveolar liquid. Pulmonary surfactant-associated protein SP-B has little effect on acyl chains in dipalmitoylphosphatidylcholine dispersions. Method of isolation. Forgot your password? Role of phosphatidylglycerol and calcium. Saunders, pp. Nevertheless, unless there is selective depletion of DPPC in the monolayer by some mechanism that has not been observed in model surfactant, the monolayer is still expected to be enriched in saturated PC, especially DPPC. Term » Abbr. Klass, E. Simon, and P. Transients that were averaged for a given spectrum were collected with a repetition time of 0. The presence of some unsaturated phospholipids such as dioleoylphosphatidylcholine [DOPC] or phosphatidylglycerol and cholesterol increases the surfactant's fluidity, so it can adsorb oxygen more efficiently.

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In the gel phase, the broader spectra reflect chain motions that are slower and no longer axially symmetric on the timescale of the experiment. Qanbar, and S. In order to determine the effects of a period of incubation on productions of ROIs, preincubation of cells with lipids was performed using the optimal dose of lipid as determined by the previous experiment. In the absence of protein, the average chain orders for DPPC- d 62 and DPPG- d 62 in the lipid mixtures were close throughout the range of temperatures studied. Nature Rev. In a mixture of one chain-perdeuterated lipid component and one normal lipid component, suppression of the transition midpoint temperature is approximately scaled in proportion to the overall extent of deuteration. Differential effects of surfactant protein A on regional organization of phospholipids monolayers containing surfactant protein B or C. The lipids were used without further purification and the concentration of lipid in each sample was determined by phosphorus analysis 42 , Protein concentrations were estimated via the fluorescamine method using bovine serum albumin as the standard 48 and were verified by amino acid analysis Club cells also produce a component of lung surfactant. This shows that, for temperatures away from the main transition, SP-A did not induce significant separation of the two lipid components.