Chem int ed engl

With an excellent Impact Factor of It appears weekly in a highly optimized, reader-friendly format; new articles appear online almost every day.

Publishing formats include feature-length reviews , short highlights, research communications , minireviews, essays, book reviews, meeting reviews, correspondences, corrections, and obituaries. This journal contains review articles covering all aspects of chemistry. According to the Journal Citation Reports , the journal had a impact factor of The editions are identical in content with the exception of occasional reviews of German-language books or German translations of IUPAC recommendations. Angewandte Chemie is available online and in print.

Chem int ed engl

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Angewandte Chemie. This title was kept until the end of when it was changed to Die Chemie.

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Cancer immunotherapies that train or stimulate the inherent immunological systems to recognize, attack, and eradicate tumor cells with minimal damage to healthy cells have demonstrated promising clinical responses in recent years. However, most of these immunotherapeutic strategies only benefit a small subset of patients and cause systemic autoimmune side effects in some patients. Immunogenic cell death ICD -inducing modalities not only directly kill cancer cells but also induce antitumor immune responses against a broad spectrum of solid tumors. Such strategies for generating vaccine-like functions could be used to stimulate a "cold" tumor microenvironment to become an immunogenic, "hot" tumor microenvironment, working in synergy with immunotherapies to increase patient response rates and lead to successful treatment outcomes. This Minireview will focus on nanoparticle-based treatment modalities that can induce and enhance ICD to potentiate cancer immunotherapy. Keywords: cancer; immunogenic cell death; immunotherapy; nanoparticles. Abstract Cancer immunotherapies that train or stimulate the inherent immunological systems to recognize, attack, and eradicate tumor cells with minimal damage to healthy cells have demonstrated promising clinical responses in recent years. Publication types Research Support, N. Substances Antineoplastic Agents.

Chem int ed engl

Nonribosomal peptide synthetases NRPSs are large multienzyme machineries that assemble numerous peptides with large structural and functional diversity. These peptides include more than 20 marketed drugs, such as antibacterials penicillin, vancomycin , antitumor compounds bleomycin , and immunosuppressants cyclosporine. Over the past few decades biochemical and structural biology studies have gained mechanistic insights into the highly complex assembly line of nonribosomal peptides. This Review provides state-of-the-art knowledge on the underlying mechanisms of NRPSs and the variety of their products along with detailed analysis of the challenges for future reprogrammed biosynthesis. Such a reprogramming of NRPSs would immediately spur chances to generate analogues of existing drugs or new compound libraries of otherwise nearly inaccessible compound structures.

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Tools Tools. Eine Zeitschrift der. Web of Science Science ed. Gesellschaft Deutscher Chemiker. Angewandte Chemie International Edition. Angewandte Chemie. Article Talk. Hudlicky responded to the backlash and retraction stating "I stand by the views I wished to express in the essay, some of which are common knowledge, while others were duly cited from primary and secondary sources". It is a hybrid open access journal and authors may choose to pay a fee to make articles available free of charge. Subsequently, he edited and republished the article on his own website. Review-type articles summarize important recent research on topical subjects across all branches of chemistry, they provide an overview of unresolved problems, and they discuss possible developments. A reflection on the current state of affair" ". Bibcode : AngCh.

Tailored to the specific tumour microenvironment, which involves acidity and the overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to generate the hydroxyl radical.

Retrieved 8 June Contents move to sidebar hide. Moreover, it is the only journal in the field delivering a stimulating mixture of Review-type articles, Highlights, Communications, and Research Articles weekly. Review-type articles summarize important recent research on topical subjects across all branches of chemistry, they provide an overview of unresolved problems, and they discuss possible developments. With an excellent Impact Factor of The editions are identical in content with the exception of occasional reviews of German-language books or German translations of IUPAC recommendations. A new editorial team was formed additionally. Toggle limited content width. The Canadian Press. Print ISSN: