Tetrahydroquinoline

Products Items of N- 1,2,3,4-Tetrahydroquinolinecarbonothioyl benzamide.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. IN connexion with work on tetrahydroquinoline derivatives of medicinal interest, we have recently synthesized a number of alkoxy- and alkyl-substituted 1,2,3,4-tetrahydroquinolines 1 in which various dialkylaminoalkyl groups carrying in some cases heterocyclic residues such as morpholino, piperidino, etc. Among the compounds tested so far, N -[2- 4-morpholino ethyl]1,2,3,4-tetrahydroquinoline I has shown interesting biological activity. Aisha Y.

Tetrahydroquinoline

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Maurya, O. Patel, D. Anand and P. Yadav, Org. To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given. If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given.

Tetrahydroquinoline is an organic compound that is the semi-hydrogenated derivative of quinoline. It is a colorless oil. Substituted derivatives of tetrahydroquinoline are common in medicinal chemistry. Tetrahydroquinolines are produced by hydrogenation of quinolines. Because the hydrogenation is reversible, tetrahydroquinoline has been often examined as a hydrogen-donor solvent in coal liquifaction.

Tetrahydroquinoline

Federal government websites often end in. The site is secure. A review of the recent literature is given focusing on synthetic approaches to 1,2,3,4-tetrahydroquinolines, 2,3-dihydro-4 1 H -quinolinones and 4 1 H -quinolinones using domino reactions. These syntheses involve: 1 reduction or oxidation followed by cyclization; 2 S N Ar-terminated sequences; 3 acid-catalyzed ring closures or rearrangements; 4 high temperature cyclizations and 5 metal-promoted processes as well as several less thoroughly studied reactions. Each domino method is presented with a brief discussion of mechanism, scope, yields, simplicity and potential utility. Domino reactions, also known as tandem or cascade reactions, have emerged as a highly effective strategy for the synthesis of bioactive natural products and pharmaceutical agents [ 1 ]. These methods enable chemists to perform complex synthetic conversions with high efficiency using simple starting materials, often via a biomimetic pathway [ 2 ]. Thus, domino reactions contribute immensely to synthetic drug design strategies, enhance aesthetic approaches in total synthesis, and improve yields in large-scale synthesis [ 1 , 2 ].

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A boronic acid catalyzed one-pot tandem reduction of quinolines to tetrahydroquinolines followed by reductive alkylation with a carbonyl compound provides N -alkyl tetrahydroquinolines in the presence of Hantzsch ester under mild reaction conditions. This may take some time to load. Buchwald, Org. Using the cyclic hydroxylamines allows for retaining both nitrogen and oxygen functionalities in the product. Neburon Login to See Price. Signal word. Sign In Don't have a profile? Search online for Assays, Antibodies, Oligos. Our Services. Company Information. EC Number.

Xiong, S.

First published 19 Jan With the proper choice of palladium catalyst, ligand, and base, five-, six-, and seven-membered rings are formed efficiently from secondary amide or secondary carbamate precursors. PCR Tubes. A chiral phosphoric acid as the sole catalyst enables an enantioselective synthesis of tetrahydroquinolines from 2-aminochalcones via chiral phosphoric acid-catalyzed dehydrative cyclization, followed by chiral phosphoric acid-catalyzed asymmetric reduction with Hantzsch ester. You must have JavaScript enabled in your browser to utilize the functionality of this website. Weighing Papers and Dishes. Generates statistical data on how the visitor uses the website. Zhang, Y. Hu, Synthesis , , 55 , Centrifugal Filter Devices.