Pyroptosis

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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease.

Pyroptosis

Metrics details. A Correction to this article was published on 22 September A Correction to this article was published on 01 July Unraveling the mystery of cell death is one of the most fundamental progresses of life sciences during the past decades. Regulated cell death RCD or programmed cell death PCD is not only essential in embryonic development, but also plays an important role in the occurrence and progression of diseases, especially cancers. Escaping of cell death is one of hallmarks of cancer. Gasdermin family proteins are the executors of pyroptosis. Pyroptosis exerts tumor suppression function and evokes anti-tumor immune responses. Therapeutic regimens, including chemotherapy, radiotherapy, targeted therapy and immune therapy, induce pyroptosis in cancer, which potentiate local and systemic anti-tumor immunity. On the other hand, pyroptosis of normal cells attributes to side effects of anti-cancer therapies. In this review, we focus on the regulatory mechanisms of pyroptosis and the tumor suppressive function of pyroptosis.

Zhao, pyroptosis, N. Canonical Pathway The canonical pathway pyroptosis pyroptosis is often described as occurring through a two-step process. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.

Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family. A great deal of evidence shows that pyroptosis can affect the development of tumors. The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds. In this review, we provide basic knowledge of pyroptosis, explain the relationship between pyroptosis and tumors, and focus on the significance of pyroptosis in tumor treatment.

Background: Unraveling the mystery of cell death is one of the most fundamental progresses of life sciences during the past decades. Regulated cell death RCD or programmed cell death PCD is not only essential in embryonic development, but also plays an important role in the occurrence and progression of diseases, especially cancers. Escaping of cell death is one of hallmarks of cancer. Gasdermin family proteins are the executors of pyroptosis. Pyroptosis exerts tumor suppression function and evokes anti-tumor immune responses.

Pyroptosis

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Pyroptosis is a novel inflammatory form of regulated cell death RCD , characterized by cell swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent inflammatory response required for maintaining organismal homeostasis.

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Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells. This study demonstrated host redirection of cell death from apoptosis to pyroptosis in activated macrophages in response to Yersinia infection. Biomed Pharmacother. Skip to main content Thank you for visiting nature. Man, S. Cancer Prev. Dysregulation of cellular signaling in gastric cancer. As an inflammatory and programmed mode of cell death, pyroptosis has been gradually elucidated with further research, but there are still some problems to be solved, such as what other factors regulate pyroptosis and what role other members of the gasdermin family play in pyroptosis. NLRP3 inflammasome in neurological diseases, from functions to therapies. Immunity 15 , —

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Binding of LPS onto these caspases promotes their oligomerization and activation. Wigler, N. Inflammasomes are cytoplasmic polyprotein complexes. Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death. Caspases and kinases in a death grip. Frantz, S. Cell 80 , — We discuss the attribution of pyroptosis in reprogramming tumor microenvironments and restoration of anti-tumor immunity and its potential application in cancer immune therapy. The role of iron and reactive oxygen species in cell death. Wen, J.