Ondansetron moa

Ondansetronsold under the brand name Zofran among others, ondansetron moa, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy ondansetron moa, radiation therapyor surgery. Common side effects include diarrheaconstipationheadachesleepinessand itchiness. Ondansetron was patented in and approved for medical use in Ondansetron is indicated for the prevention of chemotherapy-induced nausea and vomiting and postoperative nausea and vomiting.

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Ondansetron moa

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Ondansetron is one of several antiemetic drugs used during the vomiting phase of cyclic vomiting syndrome. Retrieved 29 November

Ondansetron is a highly potent and selective antagonist at 5-HT3 receptors. Its anti-emetic actions were first revealed by its ability to antagonize retching and vomiting induced by chemotherapy and radiotherapy in animals and man. Subsequently, the availability of labelled 5-HT3 receptor ligands allowed identification of 5-HT3 receptors, located at highest densities in the area postrema, nucleus tractus solitarius NTS , in other areas of the brain, and on afferent terminals of the vagus nerve. Postoperative nausea and vomiting may be caused by various factors: the anaesthetic, associated drugs, the surgical procedure, movement of the patient, sex, weight and pain. These factors mediate their effects via the higher brain circuits, the vestibular nuclei, the chemoreceptor trigger zone in the area postrema, or the upper gastrointestinal tract via the vagus nerve, influencing motor and visceral emetic outputs in the hind-brain. The absence of other pharmacological effects of ondansetron ensures an absence of side-effects.

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Ondansetron moa

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Alexandria Griddine ; Jeffrey S. Authors Alexandria Griddine 1 ; Jeffrey S. Bush 2.

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Turn recording back on. It includes the elderly or patients with electrolyte abnormalities such as hypokalemia, hypomagnesemia, heart failure, bradyarrhythmias, or patients on other medications that may prolong the QTc interval. Ondansetron has minimal efficacy against nausea and vomiting caused by motion sickness, mediated by different control centers and pathophysiologic mechanisms. Archived from the original on 28 August It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. No adverse drug reactions have been reported in infants. Anecdotally, ototoxicity has also been reported if injected too quickly. It forms synapses within the nucleus tractus solitarius of the brainstem, another region important in vomiting. Association of ABCB1 polymorphisms with the efficacy of ondansetron in chemotherapy-induced nausea and vomiting. It works on the 5-HT3 receptors that can be found at the vagus nerve terminals. Objectives: Identify the antiemetic mechanism of action of ondansetron. Adverse effects. However, 16 mg per dose IV is the maximum recommended single dose due to the risk for QTc prolongation and arrhythmias. Oncologist consultation is necessary for CINV. Archived from the original on 3 May

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Its use reduced hospital admissions, but was also associated with higher rates of return visits to the emergency department. Ondansetron comes as a tablet, a rapidly disintegrating dissolving tablet, film, and an oral solution liquid to take by mouth. Archived from the original on 1 February Products Products. It is one of the four FDA-approved 5-HT3 serotonin-receptor antagonists used to combat nausea and vomiting, including granisetron, dolasetron, and the second-generation drug, palonosetron. Ondansetron has widespread utility as an antiemetic drug and is effective against nausea and vomiting of various etiologies. Treatment poll is required to gain more useful feedback from members. Archived from the original on 28 August In the three duplicated reports, the NNT was significantly lower at 3. J Pediatr Gastroenterol Nutr. Review the importance of improving care coordination among the interprofessional team to enhance the delivery of care for patients who can benefit from therapy with ondansetron. The New England Journal of Medicine.