Ondansetron drug interactions

Ondansetron belongs to the class of medications called 5-HT3 receptor antagonists.

Ondansetron is a medicine used to prevent nausea and vomiting caused by surgery or cancer treatments. Ondansetron works by blocking serotonin, a natural substance in the brain that can trigger nausea and vomiting. The U. Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant. It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby.

Ondansetron drug interactions

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Alexandria Griddine ; Jeffrey S. Authors Alexandria Griddine 1 ; Jeffrey S. Bush 2. Ondansetron is one of the medications most commonly used for the empiric treatment of nausea and vomiting. Ondansetron has excellent utility as an antiemetic drug, and it is effective against nausea and vomiting of various etiologies. Common uses of ondansetron include the prevention of chemotherapy-induced and radiation-induced nausea and vomiting, the prevention of postoperative nausea and vomiting, and off-label use for the prevention of nausea and vomiting associated with pregnancy. However, it is not effective for motion sickness-induced nausea. This activity will cover the mechanism of action, pharmacology, adverse event profiles, eligible patient populations, contraindications, and monitoring. It also highlights the interprofessional team's role in managing patients needing ondansetron therapy. Objectives: Identify the antiemetic mechanism of action of ondansetron.

Phenylketonuria: People with phenylketonuria lacking the enzyme needed to break down phenylalanine should take forms of ondansetron other than oral dissolving tablets ODT. Use of ondansetron during the first trimester of pregnancy can increase the risk of birth defects. The patient required endotracheal intubation, supportive care, and lorazepam for seizures, ondansetron drug interactions.

Purpose: Both ondansetron and cyclophosphamide are thought to be metabolized by hepatic microsomal processes. The purpose of this study was to evaluate the potential pharmacokinetic interactions between ondansetron and high-dose alkylating agent chemotherapy. Methods: A total of 54 breast cancer patients receiving high-dose cyclophosphamide, cisplatin and carmustine were treated prospectively in four sequential cohorts. Cohorts I and II received continuous infusions of both ondansetron and prochlorperazine, and cohorts III and IV received a continuous infusion of ondansetron alone at the same doses. All patients received lorazepam every 4 h. A group of 75 matched historical controls had received a continuous infusion of prochlorperazine with lorazepam. Pharmacokinetic monitoring of each drug used in the high-dose chemotherapy regimen was conducted.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of ondansetron in children younger than 4 years of age.

Ondansetron drug interactions

Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetron , known under the brand name Zofran , is a selective 5-HT3 receptor antagonist that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapy , treatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting. Ondansetron is available as an injection, an oral solution, an oral tablet, and an orally-disintegrating tablet. Ondansetron interactions with amiodarone, domperidone, methadone, specific antiarrhythmic and antibiotic medications, and serotonergic agents. Ondansetron can also affect the metabolism of other medicines, exacerbating side effects associated with individual drugs. The most serious medications that ondansetron interferes with include certain antiarrhythmics, antibiotics, and serotonergic medications. As a selective 5HT3 receptor antagonist , Ondansetron blocks serotonin peripherally and centrally. Therefore, combining with other medications in the 5HT3 receptor antagonist class will increase the potential risk. Monoamine oxidase inhibitors , or MAOIs, were the first class of antidepressants developed. These medications work by blocking an enzyme , monoamine oxidase, which removes serotonin from the brain.

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Tell your doctor or prescriber about all prescription, over-the-counter non-prescription , and herbal medications you are taking. Aminophylline is predicted to cause hypokalaemia potentially increasing the risk of torsade de pointes when given with Ondansetron. The elimination half-life after an 8 mg oral or intravenous dose is approximately h in adults, but on average, it is 5. Health Conditions A-Z. These at-risk groups include patients with electrolyte abnormalities such as hypokalemia, hypomagnesemia, heart failure, bradyarrhythmias, or patients on other medications that may prolong the QTc interval. Both Ondansetron and Almotriptan can increase the risk of serotonin syndrome. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Both Ondansetron and Duloxetine can increase the risk of serotonin syndrome. Adenosine binding cassette subfamily 1 ABCB1 is a drug efflux transporter known to transport ondansetron across the blood-brain barrier, thus limiting its accumulation in the CNS. Coma and death are possible. If you are taking any of these medications, speak with your doctor or pharmacist.

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Call your doctor for medical advice about side effects. As a selective 5HT3 receptor antagonist , Ondansetron blocks serotonin peripherally and centrally. Monoamine oxidase inhibitors , or MAOIs, were the first class of antidepressants developed. Both Ondansetron and Pimozide prolong the QT interval. Tell your doctor if you are pregnant. Many medications can cause side effects. Both Ondansetron and Methadone can increase the risk of serotonin syndrome. Formoterol is predicted to cause hypokalaemia potentially increasing the risk of torsade de pointes when given with Ondansetron. Both Ondansetron and Sertraline can increase the risk of serotonin syndrome. This medicine may cause a serious heart problem called myocardial ischemia low blood supply to the heart. Ondansetron acts both centrally and peripherally to prevent and treat nausea and vomiting. Dosing varies depending on the route of administration and the etiology. Be careful if you drive or do anything that requires you to be alert. Follow all directions on your prescription label.