Maria tokuyama

Mission Statement: As citizens of the scientific biosphere, we value representation of diverse individuals maria tokuyama advance science and enrich the scientific community.

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Maria tokuyama

Google Scholar. Tokuyama lab. Tokuyama has always been interested in the interaction between viruses and the immune system. As an undergrad at University of California, Irvine, she worked in an infectious disease lab that focused on HIV research and obtained her B. Tokuyama obtained her Ph. Tokuyama trained at Yale University in the Department of Immunobiology, where she became fascinated by endogenous retroviruses and established the foundation for the research that she will carry out at UBC. In the past year, Dr. The overarching goal of our lab is to identify immunological mechanisms that underlie heterogeneity in disease outcomes. Our lab seeks to understand how interactions between the immune system and the virome influence outcomes of viral infection and autoimmunity. In particular, we are focused on uncovering immunomodulatory functions of endogenous retroviruses ERVs , which are retroviral sequences that make up a large fraction of the human genome. Using clinical samples, in vivo mouse models and 2D and 3D cell cultures, we seek to uncover how endogenous viral proteins affect immune cell signaling and function in health and disease through transcriptomic, proteomic and functional assays. Furthermore, we will employ computational analysis methods to study endogenous viral elements to deepen our understanding of how these elements are regulated and their potential roles in clinical outcomes. Ultimately, our goal is to identify novel biomarkers and develop biologics that mimic beneficial ERV-immune interactions while blocking detrimental interactions to prevent and treat viral infections and chronic inflammatory diseases. We currently have multiple projects aimed at uncovering how the interaction between ERVs and the immune system impacts antiviral immunity and excessive inflammation in autoimmunity. We rely on multidisciplinary approaches and novel tools in virology, immunology, and computational genomics.

Maria tokuyama overarching goal of our lab is to identify immunological mechanisms that underlie heterogeneity in disease outcomes. Kidney 2 6,

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Mission Statement: As citizens of the scientific biosphere, we value representation of diverse individuals who advance science and enrich the scientific community. We welcome scientists from underrepresented backgrounds, and as a team, we are committed to reforming institutional culture and policies that perpetuate racism and exclusion in science. Lab Research: The core of our research is to understand how chronic interaction between viruses and the immune system impacts immunity at steady state and during inflammation. We study endogenous retroviruses ERVs , which are viral sequences in our genome that originated from exogenous viruses and have undergone an evolutionary arms race with the host for millions of years. We currently have multiple projects aimed at uncovering how the interaction between ERVs and the immune system impacts antiviral immunity and excessive inflammation in autoimmunity. We rely on multidisciplinary approaches and novel tools in virology, immunology, and computational genomics. Ultimately, our goal is to identify novel endogenous viral factors that underlie immunity and contribute towards development of immune modulators to treat infections and chronic inflammatory diseases.

Maria tokuyama

Since March , severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 has drastically changed our lives and has killed over four million people worldwide. Data analysis from New York City Health found that of all death cases Several research studies have shown that differences in immune response and metabolism during disease may partly explain the worse outcomes in males than females. Here, we will summarize the key takeaways from those studies.

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Ultimately, our goal is to identify novel endogenous viral factors that underlie immunity and contribute towards development of immune modulators to treat infections and chronic inflammatory diseases. Nature medicine 27 7 , , Google Scholar. Journal of Experimental Medicine 7 , e , Lab Name. Support us. Get my own profile Cited by All Since Citations h-index 21 19 iindex 24 Med 2 3 , Lab Location. The overarching goal of our lab is to identify immunological mechanisms that underlie heterogeneity in disease outcomes. Research Group. The system can't perform the operation now. Using clinical samples, in vivo mouse models and 2D and 3D cell cultures, we seek to uncover how endogenous viral proteins affect immune cell signaling and function in health and disease through transcriptomic, proteomic and functional assays. Ultimately, our goal is to identify novel endogenous viral factors that underlie immunity and contribute towards development of immune modulators to treat infections and chronic inflammatory diseases. Financial Support.

Google Scholar. Tokuyama lab. Tokuyama has always been interested in the interaction between viruses and the immune system.

Tokuyama obtained her Ph. Sign in. New citations to this author. Research Interests. Student Resources. Office Location. Nature medicine 27 7 , , Emerging infectious diseases 27 4 , , New England Journal of Medicine 13 , , The system can't perform the operation now. Using clinical samples, in vivo mouse models and 2D and 3D cell cultures, we seek to uncover how endogenous viral proteins affect immune cell signaling and function in health and disease through transcriptomic, proteomic and functional assays. Ongoing Projects Open Close.