Lymphocytic infiltration

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DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages. Home arrow-right-small-blue Topics A—Z arrow-right-small-blue Jessner lymphocytic infiltrate. Jessner lymphocytic infiltrate is an uncommon skin condition that presents as non- scaly red patches and lumps on the face, neck and upper back. They are usually painless and do not itch.

Lymphocytic infiltration

Degree of lymphocyte infiltration in 8 specimens with cervical node—positive and 12 specimens with cervical node—negative findings in undifferentiated nasopharyngeal cancer. Bar indicates SE; mpf, medium power-fields. Lymphocytic Infiltration in Undifferentiated Nasopharyngeal Cancer. Arch Otolaryngol Head Neck Surg. Background Undifferentiated nasopharyngeal carcinoma NPC is characterized by prominent lymphocytic infiltration. Although the lymphoid infiltrate in NPC has been examined extensively in morphologic and immunocytochemical studies, the significance of this lymphoid infiltrate and its correlation with prognosis has been a subject of controversy for years. Objective To elucidate the significance of lymphoid infiltration in undifferentiated NPC. Design Evaluation of the relationship between lymphocytic infiltration in NPC and cervical lymph node status, ultrastructural examination of the lymphoid infiltrate, and assessment of lymphocytic infiltration as an independent prognosticator of regional node metastasis. Materials and Methods Lymphocytic infiltration was evaluated quantitatively in 20 cases of undifferentiated NPC using light microscopy. Four cases of undifferentiated NPC were processed for conventional electron microscopy. The effects of degree of lymphocytic infiltration, age, and tumor stage on cervical nodal metastasis were analysed using the logistic regression model. Ultrastructural evidence of lymphocytes destroying cancer cells was seen. Conclusions The lymphoid infiltrate is beneficial in undifferentiated NPC, and its presence may deter regional metastasis of cancer cells to the cervical nodes. The predominant type, undifferentiated carcinoma, has been described previously as a lymphoepithelioma. On the one hand, the lymphoid infiltrate is thought to represent a local immune reaction against NPC and is associated with a good prognosis.

Mycosis fungoides MF is a chronic disorder of the lymph that progresses over time.

Last updated: November 27, Years published: , , , , , , Lymphocytic infiltrate of Jessner is a rare skin condition that may be characterized by non-cancerous benign buildup of white blood cells, which present as lesions or lumps on the skin. These lesions may be seen on areas including the face, neck, upper extremities, shoulders, and upper back skin most exposed to sunlight. Although the lesions are typically not painful, patients with lymphocytic infiltrate of Jessner may experience itchiness and redness. Presentation can vary, for example, the lesions may remain unchanged for several years and resolve. Other patients may go through worsening of symptoms for years.

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Lymphocytic infiltration

Lymphocytic interstitial pneumonia LIP is lymphocytic infiltration of the alveolar interstitium and air spaces. The cause is unknown. Symptoms and signs are cough, progressive dyspnea, and crackles. Diagnosis is based on history, physical examination, imaging tests, and lung biopsy. Treatment is with corticosteroids, cytotoxic drugs, or both, although efficacy is unknown. Prognosis is largely unknown and limited to case-series. Lymphocytic interstitial pneumonia is a rare idiopathic interstitial pneumonia Overview of Idiopathic Interstitial Pneumonias Idiopathic interstitial pneumonias IIPs are interstitial lung diseases of unknown etiology that share similar clinical and radiologic features and are distinguished primarily by the histopathologic Non-necrotizing, poorly formed granulomas may be present but are usually rare and inconspicuous. LIP is the most common cause of pulmonary disease after Pneumocystis infection Pneumocystis jirovecii Pneumonia Pneumocystis jirovecii , an atypical fungus, is a common cause of pneumonia in immunosuppressed patients, especially in those infected with human immunodeficiency virus HIV and in those

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Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. The others markers did not vary in a consistent way. Statistical methods. Publication types Study Guide. Semin Oncol. Photo Required Max file size 5MB. J Transl Med 11 , Results were tabulated to estimate the evolution in time of each marker for one patient. The team may include a rheumatologist if an autoimmune component is present, and if multiple family members are affected, it would be best to counsel the family as a unit about the likelihood of a genetic component to the disease. Full size image. The list of disorders that overlap clinically and histologically with JLI is vast, indicating that JLI is probably not a separate entity, but rather a clinicopathologic reaction pattern common to different skin diseases [ ]. Introduction Jessner lymphocytic infiltration of the skin JLIS is the term used to describe a rare, benign cutaneous condition characterized by papular or plaque-like eruptions that commonly involve sun-exposed areas such as face, neck, and trunk. Plasmacytoid monocytes, also called plasmacytoid dendritic cells, are larger than lymphocytes with a pale nucleus and a relatively large single nucleolus. Of the three evaluable MF CTCL partial responders PR 25, 31, and 36 , one showed increase in the cellular infiltrate while it remained unchanged for the two other patients.

However, since the original description by Jessner and Kanof in [ 1 ], the existence of JLI as a distinct disease has been questioned [ 2 ].

Phone This field is for validation purposes and should be left unchanged. In this Page. Trial registration The phase I step TG J Pathol. Formulary drug information for this topic. Introduction Lymphocytic infiltrate of Jessner has been thought to fall in the same spectrum as the autoimmune disease known as lupus tumidus or discoid lupus erythematosus. Although the limited number of patients included in this work would not allow statistical analysis, the equal distribution between responders and non-responders tends to show that there is no association between the stage of disease at baseline and the clinical outcome following the treatment. Last updated: November 27, Years published: , , , , , , Intralesional delivery of human IFN-g-expressing adenovirus allows reaching high local concentrations of this cytokine, as shown by quantitative RT-PCR in 7 out of 9 patients following the first treatment cycle. Similar results were seen in regressing CTCL tumors after intralesional administration of IL [ 14 ] or after injection with adenovirus-engineered IL-2 expressing autologous plasma cells [ 22 ]. After persisting for several months or years, lesions disappear spontaneously without leaving scars or causing other problems.