Euronetwork

Background and purpose: To describe the characteristics of patients presenting a paraneoplastic cerebellar degeneration without classical euronetwork antibodies seronegative PCD, euronetwork. No significant difference euronetwork the clinical characteristics of seronegative and seropositive PCD patients was observed. Yet the frequency of associated tumors was different.

Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed.

Euronetwork

Close X. Select your language. Log out EU Login Log out. English EN. My subscriptions My saved searches My Booklet My profile. Log in. Fact Sheet Results in Brief Reporting. The database included the 'classical' PNS plus several others, less-well characterised syndromes in association with cancer. Cerebellar degeneration and sensory neuronopathy were the most frequent syndromes followed by limbic encephalitis, Paraneoplastic neurological syndromes PEM and brainstem encephalitis; these classical PNS confirmed the clinical profile already reported in the literature. A remarkable finding in this group of syndromes was the Rankin scale analysis that showed that patients with cerebellar degeneration and Yo antibodies had a higher level of disability than did cases with other onconeural antibodies. The antibody types were within the spectrum for onconeuronal antibodies and, in association with a PNS, had significant diagnostic value for an underlying cancer.

Follow this company File for this company, euronetwork. The clinical profile of collected syndromes in our study confirms the results of previous studies euronetwork - 14 but is based on a much larger case series. Skip to main content.

Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives: To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Design: Prospective case series and database study. Setting: Twenty European centers. Patients Patients were recruited from January 1, , to December 31, Main outcome measures: Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed.

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Euronetwork

Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed. Results Data from patients were analyzed, representing the largest PNS investigation to date. The findings elucidate the clinical evolution of paraneoplastic cerebellar syndrome according to the onconeural antibodies present, the heterogeneity and prognosis of dysautonomic disorders, and the clinical variability of paraneoplastic limbic encephalitis. Conclusion The study results confirm that PNS influences oncologic patient survival. Tumors are the main cause of death, but some types of PNS such as dysautonomia have a poorer prognosis than malignant neoplasms.

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Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. The preferred treatment in the cohort was intravenous immunoglobulin, 19 , 20 probably because of easy availability. Sign in to access free PDF. Privacy Policy Terms of Use. Diagnoses were according to the Graus criteria. The methods used by each center were reported in the database. Company type Private limited Company Incorporated on 6 September Results Data from patients were analyzed, representing the largest PNS investigation to date. Free access to newly published articles. None of these patients had Hu antibodies. At each center, a trained neurologist was responsible for data collection. Accounts Next accounts made up to 30 September due by 30 June Last accounts made up to 30 September All other antibodies had frequencies below The relative distribution of disorders confirms cerebellar degeneration and SN as the most frequently appearing types of PNS.

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Although the database was not designed for epidemiologic studies, we believe that our data represent the prevalence of each syndrome. This finding of clinical manifestation of PNS in the absence of antibody reactivity is a significant finding. In patients with PCD, the most frequent findings were subacute onset of moderate The tumor diagnosis was histologically definite in We'd also like to use analytics cookies so we can understand how you use our services and to make improvements. I accept cookies. Design: Prospective case series and database study. The hematologic diseases such as lymphoma and Hodgkin disease rarely manifested as PNS. The patients were followed up throughout the course of their disease and were recorded at the end of the study period as being alive, dead, or lost to follow-up. Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. You can change your cookie settings at any time. Log in. Data quality assessment was performed continuously, and structured group meetings were held to assess data quality, exchange results, and discuss recent developments.