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Federal government websites often end in. The site is secure. The genetic component of Immunoglobulin-A IgA vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study GWAS on this condition. After quality control filters and GWAS imputation, patients and 1, controls remained in the datasets and were included in further analysis.
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Nonetheless, it is important to keep in mind that the number of cases recruited in our study was not high and replication was not carried out.
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Outside the HLA, potential associations were detected, but none of them were close to the statistical significance. This study aimed at conducting the first GWAS of IgA vasculitis using the largest series of IgA vasculitis patients of European ancestry ever assessed for a genetic study. The action and emotion showed during the Nations Cup races and World Championship final today was truly inspiring. The site is secure. N Engl J Med. Nat Genet. However, the genetic component of this type of vasculitis remains poorly understood, as only a few candidate gene studies have been performed to date 4 , 5. Purcell S, et al. The eSailing Nations Cup final saw France take on Great Britain in the live virtual final, while the eSailing World Championship featured the ten qualifiers in a winner take all. Am J Hum Genet.
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Although the classic clinical triad of IgA vasculitis consists of palpable purpura involving the lower extremities , joints and the gastrointestinal tract, renal complications may also develop in affected individuals 2. Genetically distinct subsets within ANCA-associated vasculitis. Next Story. Nonetheless, it is important to keep in mind that the number of cases recruited in our study was not high and replication was not carried out. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. IgA vasculitis has a multifactorial etiology in which both environmental and genetic factors seem to contribute to the predisposition and clinical phenotype of the disease 1 , 3. Arthritis Res Ther. Received Jan 26; Accepted May 5. Acknowledgements We wish to thank all the patients with IgA vasculitis and controls for their participation in this study. Considering that IgA vasculitis is an immune-mediated condition, a more comprehensive analysis of the HLA region was conducted. PLINK: a tool set for whole-genome association and population-based linkage analyses. PLoS One. All participants or their parents signed an informed consent form before being enrolled in the study. Medicine Baltimore.
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