Angel dust drug wiki

Phencyclidine a shortened version of the chemical name phenylcyclohexylpiperidineusually called PCPis angel dust drug wiki illegal drug. PCP is called a hallucinogenic drug: it causes people to hallucinateand see, hear, and sense things that are not real.

Editor-In-Chief: C. Michael Gibson, M. Phencyclidine a contraction of the chemical name phenylcyclohexylpiperidine , abbreviated PCP , is a dissociative drug formerly used as an anesthetic agent, exhibiting hallucinogenic and neurotoxic effects. It was first patented in by the Parke-Davis pharmaceutical company and marketed under the brand name Sernyl. In chemical structure, PCP is an aryl cyclohexyl amine derivative, and, in pharmacology , it is a member of the family of dissociative anesthetics. Although the primary psychoactive effects of the drug last only hours, total elimination from the body is prolonged, typically extending over weeks. More than 30 different analogues of PCP were reported as being used on the street during the s and s, mainly in the USA.

Angel dust drug wiki

Phencyclidine chemical structure Phencyclidine. Phencyclidine a complex clip of the chemical name phenylcyclohexylpiperidine , commonly initialised as PCP , is a dissociative drug formerly used as an anesthetic agent, exhibiting hallucinogenic and neurotoxic effects. In chemical structure, PCP is an arylcyclohexylamine derivative, and, in pharmacology , it is a member of the family of dissociative anesthetics. Although the primary psychoactive effects of the drug last only hours, total elimination from the body is prolonged, typically extending over weeks. The N-methyl-D-Aspartate NMDA receptor , a type of ionotropic receptor , is found on the dendrites of neurons and receives signals in the form of neurotransmitters. It is a major excitatory receptor in the brain. Normal physiological function requires that the activated receptor fluxes positive ions through the channel part of the receptor. PCP enters the ion channel from the outside of the neuron and binds, reversibly, to a site in the channel pore, blocking the flux of positive ions into the cell. PCP therefore inhibits depolarization of neurons and interferes with cognitive and other functions of the nervous system. In some brain regions, these effects act synergistically to inhibit excitatory activity. The most troubling clinical effects are likely produced by the indirect action of phencyclidine on the presynaptic dopamine receptor DA This has been suggested to account for most of the psychotic features. More than 30 different analogues of PCP were reported as being used on the street during the s and s, mainly in the USA.

The smaller the value, the more strongly the drug binds to the site.

PCP may cause psychosis and mania at a significantly higher rate than other dissociatives. It is strongly discouraged to use this substance in high doses or multiple days in a row. Please see this section for more details. WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Phencyclidine also known as PCP , Angel Dust , Sherm , and Sernyl [6] is a classical dissociative substance of the arylcyclohexylamine class.

PCP phencyclidine is a dissociative drug. PCP is mostly abused by young adults. Despite the common belief that hallucinogens are harmless, PCP is addictive. Long-term abuse may cause health problems and overdose can be fatal. But phencyclidine is still available as a street drug throughout the country. You can most commonly find PCP as a white crystalline powder or liquid. It also comes in tablet or pill form.

Angel dust drug wiki

PCP, also known as phencyclidine and angel dust, was originally developed as a general anesthetic but became a popular substance in the s. Healthline does not endorse the use of any illegal substances, and we recognize abstaining from them is always the safest approach. However, we believe in providing accessible and accurate information to reduce the harm that can occur when using. PCP can be ingested orally, snorted, smoked, or injected, depending on its form. It can be found in tablets and capsules. Most people smoke it by sprinkling it on cannabis , tobacco, or plant leaves like mint or parsley. People also dissolve it in a liquid and dip cigarettes or joints in the solution. PCP causes psychological and physical effects that can be unpredictable, especially in larger doses.

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Like other NMDA receptor antagonists , it is postulated that phencyclidine can cause a certain kind of brain damage called Olney's Lesions. All of these analogues would have somewhat similar effects to PCP itself, although, with a range of potencies and varying mixtures of anesthetic, dissociative and stimulant effects depending on the particular substituents used. Phencyclidine has also been shown to cause schizophrenia -like changes in the rat brain, which are detectable both in living rats and upon post-mortem examination of brain tissue. PCP enters the ion channel from the outside of the neuron and binds, reversibly, to a site in the channel pore, blocking the flux of positive ions into the cell. Sign in to edit. Retrieved January 1, Legal status. Los Angeles street gangs continue to control both production and distribution of PCP. In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, PCP seems to exhibit almost identical bladder and urinary tract problems to those produced by ketamine. National Drug Intelligence Center. Manual of forensic emergency medicine : a guide for clinicians. Toggle limited content width. Retrieved on November 3, through Google Book Search.

Phencyclidine or phenylcyclohexyl piperidine PCP , also known in its use as a street drug as angel dust among other names, is a dissociative anesthetic mainly used recreationally for its significant mind-altering effects. Adverse effects may include seizures , coma , addiction , and an increased risk of suicide. PCP is most commonly used in the United States.

B Biol. Schizophrenia Research 73 : — Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogs. At low doses, people can also have sensory distortions changes in how they hear, see, taste, smell, or feel things ; amnesia where the person cannot remember things normally ; speech which does not make sense; blurred vision; or a blank stare. Nine percent of ingested PCP is excreted in its unchanged form. Recent use of phencyclidine or a pharmacologically similar substance. Drug Testing and Analysis. European Journal of Pharmacology. Because of its adverse side-effects , such as hallucinations , mania , delirium , and disorientation , it was shelved until the s. More than 30 different analogues of PCP were reported as being used on the street during the s and s, mainly in the USA. Journal of Clinical Pharmacology. It is a major excitatory receptor in the brain. Orange Book. In one initial human trial, it was reported that one-sixth of the patients who had received anesthetic doses experienced acute psychosis.