Alpha inhibin

Inhibin is a peptide hormone that is produced by ovarian granulosa cells which alpha inhibin the release of Follicle-Stimulating Hormone FSH. The Inhibin alpha antibody subunit is expressed in a wide range of human tissues outside the reproductive axis such as prostate, brain, adrenal, as well as in the granulosa cells of the ovary, Sertoli cells of the testis and various cells of the fetoplacental unit. Inhibin may be used as a differential marker for adrenocortical tumors, alpha inhibin, placenta and gestational trophoblastic lesions and sex cord stromal tumors. Normal testis or normal ovary, adrenal alpha inhibin.

Click here to buy online! Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex-cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibin contains an alpha and beta subunit linked by disulfide bonds. Two forms of inhibin differ in their beta subunits A or B , while their alpha subunits are identical. Inhibin belongs to the transforming growth factor-beta TGF-beta family.

Alpha inhibin

It appears that your browser has cookies disabled. The website requires your browser to enable cookies in order to login. Don't have a login? Register today to view list prices and apply for an account to purchase online! Inhibins and activins play a role in the regulation of pituitary follicle stimulating hormone FSH secretion. The actions of inhibins and activins are thought to oppose one another, with inhibins suppressing FSH secretion and activins stimulating FSH secretion. Inhibins are secreted by granulosa cells in female follicles and Sertoli cells of the testis in the male. Inhibins are thought to have local regulatory roles in a variety of tissues, in addition to the ovary, including the brain, adrenal glands, bone marrow, fetus and placenta. Inhibin Alpha is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. You may place your order and it will be fulfilled when the product is back in stock. Product availability is limited, but products are in continuous production.

Neuroendocrine tumors.

Federal government websites often end in. The site is secure. As a result of its expression in corresponding normal cell types, inhibin alpha INHA is used as an immunohistochemical marker for adrenocortical neoplasms and testicular or ovarian sex cord stromal tumors. However, other tumors can also express INHA. To comprehensively determine INHA expression in cancer, a tissue microarray containing 15, samples from different tumor types and subtypes was analyzed by immunohistochemistry.

Check out our latest pathology themed Wordle here! Updated every Monday. Editorial Board Member: Christian M. Page views in 13, Cite this page: Wirth P. Accessed March 7th, Dimeric glycoprotein consisting of alpha and beta subunits that is mainly produced in the gonads Regulates follicle stimulating hormone FSH secretion through negative feedback mechanisms with paracrine and autocrine actions on gonads and adrenal glands. Essential features.

Alpha inhibin

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Non-invasive papillary urothelial carcinoma, pTa G3. Inhibin may be used as a differential marker for adrenocortical tumors, placenta and gestational trophoblastic lesions and sex cord stromal tumors. All authors agree to be accountable for the content of the work. Related Products Details. Contributed by Pamela Wirth, Ph. Inhibin alpha Inhibin beta Folliculostatin. Inhibin has also been suggested to inhibit gonadal stromal cell proliferation and to possess a tumor suppressive activity [ 4 ]. From January you will begin to receive products with a —U, —A or —X suffix e. Clear cell tubulo papillary renal cell carcinoma. Product is out of stock. For raw data and references, see Table S1. Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Answers A and B are incorrect because inhibin is typically negative or weakly expressed in these tumor types.

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease.

However, we cannot answer medical or research questions or give advice. In summary, these data support the use of INHA antibodies for detecting sex cord stromal tumors, granular cell tumors, and adrenocortical neoplasms. All these cell types also stained positive if the monoclonal mouse anti-human inhibin alpha antibody clone R1 was used Figure S1. Microscopic examination of the biopsy revealed sheets of tumor cells arranged in a trabecular pattern. Hybridoma 9 1 : 2. To ensure as broad as possible a range of proteins to be tested for possible cross-reactivity, 76 different normal tissue categories were included in this analysis. Your order will be processed as normal and may take additional days to ship. Lost your password? Adenocarcinomas of various sites may exhibit immunoreactivity with anti-inhibin antibodies. Inhibin contains an alpha and beta subunit linked by disulfide bonds. All authors have read and agreed to the published version of the manuscript. Sangoi A. No item added to cart The replacement product is no longer available, no item has been added to cart. Weissferdt A.