2 hydroxy p naphthoquinone

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2 hydroxy p naphthoquinone

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A hydroxynaphthoquinone formula: C 10 H 6 O 3 is any of several organic compounds that can be viewed as derivatives of a naphthoquinone through replacement of one hydrogen atom H by a hydroxyl group -OH. In this case the number n which is between 1 and 6 is indicated by a multiplier prefix mono -, di -, tri -, tetra -, penta -, or hexa -. The unqualified term "hydroxynaphthoquinone" usually means a derivative of 1,4-naphthoquinone. Other hydroxy- compounds can be derived from other isomers of the latter, such as 1,2-naphthoquinone and 2,6-naphthoquinone. The hydroxynaphtoquinones in the particular or the general sense include many biologically and industrially important compounds, and are a building-block of many medicinal drugs. From 1,2-naphthoquinone ortho -naphthoquinone there are 6 possible isomers:. From 2,3-naphthoquinone , also a symmetric molecule there are only three isomers:. From the symmetrical 2,6-naphthoquinone amphi -naphthoquinone there are only three:. Contents move to sidebar hide.

2 hydroxy p naphthoquinone

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The treatment of Staphylococcus aureus S. Here, we report the synthesis of a lawsone 2-hydroxy-1,4-naphthoquinone -based compound as an antimicrobial agent against methicillin-resistant S. A series of lawsone-derivative compounds were synthesized by means of tuning the lipophilicity of lawsone and screened for minimum inhibitory concentrations against MRSA to identify a candidate compound that possesses a potent antibacterial activity. The identified lawsone-derivative compound exhibited significantly improved drug resistance profiles against MRSA compared to conventional antibiotics. The therapeutic efficacy of the compound was validated using murine models of wound infection as well as non-lethal systemic infection induced by MRSA. Our study further revealed the multifaceted modes of action of the compound, mediated by three distinctive mechanisms: 1 cell membrane damage, 2 chelation of intracellular iron ions, and 3 generation of intracellular reactive oxygen species.

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Biological Buffers. Technical cookies required These cookies are necessary to give you secure access to areas with personal information or to recognise you when you log in. If you do not allow the use of analytical and marketing cookies, we will not be able to offer you improvements in the use of the website. Estimated delivery in Latvia, on Monday 25 Mar Weighing Papers and Dishes. Other solubilities: soluble in benzene,carbon tetrachloride,aceton,,petroleum ether and sodium hydroxide Formula Weight Ref: TM-T mg Description This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. View All Molecular Biology. Syringes and Needles.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio.

Here you can modify parameters that will directly affect your browsing experience on this website. Estimated delivery in Latvia, on Tuesday 26 Mar You can also set your preferences by clicking "Settings". Syringe Filters. This search does not contain any category. Biological Buffers. Request quotation. All Syringes and Needles. This item is not returnable. Ref: 3B-H 25g