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Phospholipase D PLD is a potential therapeutic target against cancer. However, the contribution of PLD inhibition to the antitumor response remains unknown. We developed a potent and selective PLD1 inhibitor based on computer-aided drug design. The inhibitor enhanced apoptosis in colorectal cancer CRC cells but not in normal colonic cells, and in vitro cardiotoxicity was not observed. In cancer, therapeutic engagement of immunogenic cell death ICD leads to more effective responses by eliciting the antitumor immunity of T cells.

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Lau 4,5,6,7 , Kenneth K. Leung 4 , Adrienne Y. Chan 4,5,6,10 , Celine S. Chui 6,11,12 , Ian C. Wong 4,5,6,7,13 , Ju-Young Shin 1,2, Background Polypharmacy among older people represents a global challenge due to its association with adverse drug events. The reported prevalence of polypharmacy varies widely across countries, and is particularly high in Asian countries. However, there is no multinational study using standardised measurements exploring variations in prescribing trends. Design Multinational, retrospective, time-trend, observational study using a common study protocol. We estimated the annual prevalence of polypharmacy and calculated average annual percentage change AAPC to assess the time trends. Results A total of 1.

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Lee was in a relationship with Jun Hyun-moo , a former announcer turned broadcast personality and host. This biographical article about a South Korean personality is a stub. You can help Wikipedia by expanding it. This Asian biographical article related to television is a stub. Contents move to sidebar hide. Article Talk. Read Edit View history. Tools Tools.

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